If Genesis 21 begins with God remembering Sarah – promising her a pregnancy and the subsequent birth of Isaac, Genesis 22 begins with forgetting Sarah.
Abraham packs up his camels early so not to wake her, ask her opinion (about their son), or give her time to say her goodbyes.
And in Genesis 23, immediately following this story, we read: “And Abraham came to mourn Sarah”.
Rabbis are cited in the midrash as connecting these two events –attributing the cause of Sarah’s death to the binding and near death of her son, Isaac.
Information on the Indian Act: Here
A Jewish Feminist reading of Genesis 22: Here
Archeological information on Mesopatemia: Here